Anti‐inflammatory therapies in myocardial infarction: failures, hopes and challenges
In the infarcted heart, the damage‐associated molecular pattern proteins released by
necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of …
necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of …
All roads lead to Rome (the heart): cell retention and outcomes from various delivery routes of cell therapy products to the heart
In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …
the feasibility of cell transplantation in treating heart diseases. Over the years, different …
Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges
In the infarcted myocardium, necrotic cardiomyocytes release danger signals, activating an
intense inflammatory response. Inflammatory pathways play a crucial role in regulation of a …
intense inflammatory response. Inflammatory pathways play a crucial role in regulation of a …
Towards comprehensive cardiac repair and regeneration after myocardial infarction: Aspects to consider and proteins to deliver
Ischemic heart disease is a leading cause of death worldwide. After the onset of myocardial
infarction, many pathological changes take place and progress the disease towards heart …
infarction, many pathological changes take place and progress the disease towards heart …
[HTML][HTML] Beyond endothelial cells: vascular endothelial growth factors in heart, vascular anomalies and placenta
JP Laakkonen, J Lähteenvuo, S Jauhiainen… - Vascular …, 2019 - Elsevier
Vascular endothelial growth factors regulate vascular and lymphatic growth. Dysregulation
of VEGF signaling is connected to many pathological states, including hemangiomas …
of VEGF signaling is connected to many pathological states, including hemangiomas …
Regenerative medicine for the heart: perspectives on stem-cell therapy
GS Cho, L Fernandez, C Kwon - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Despite decades of progress in cardiovascular biology and medicine, heart
disease remains the leading cause of death, and there is no cure for the failing heart. Since …
disease remains the leading cause of death, and there is no cure for the failing heart. Since …
Stem cell therapy for the heart: blind alley or magic bullet?
AAN Bruyneel, A Sehgal, S Malandraki-Miller… - Journal of …, 2016 - Springer
When stressed by ageing or disease, the adult human heart is unable to regenerate, leading
to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has …
to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has …
Human cardiac progenitor spheroids exhibit enhanced engraftment potential
A major obstacle to an effective myocardium stem cell therapy has always been the delivery
and survival of implanted stem cells in the heart. Better engraftment can be achieved if cells …
and survival of implanted stem cells in the heart. Better engraftment can be achieved if cells …
Safety of intracoronary infusion of 20 million C-kit positive human cardiac stem cells in pigs
Background There is mounting interest in using c-kit positive human cardiac stem cells (c-
kitpos hCSCs) to repair infarcted myocardium in patients with ischemic cardiomyopathy. A …
kitpos hCSCs) to repair infarcted myocardium in patients with ischemic cardiomyopathy. A …
Macrophage Heterogeneity in Myocardial Infarction: Evolution and Implications for Diverse Therapeutic Approaches
Given the extensive participation of myeloid cells (especially monocytes and macrophages)
in both inflammation and resolution phases post-myocardial infarction (MI) owing to their …
in both inflammation and resolution phases post-myocardial infarction (MI) owing to their …