Primate segmental duplications: crucibles of evolution, diversity and disease
Compared with other mammals, the genomes of humans and other primates show an
enrichment of large, interspersed segmental duplications (SDs) with high levels of sequence …
enrichment of large, interspersed segmental duplications (SDs) with high levels of sequence …
Differences between human and chimpanzee genomes and their implications in gene expression, protein functions and biochemical properties of the two species
MV Suntsova, AA Buzdin - BMC genomics, 2020 - Springer
Chimpanzees are the closest living relatives of humans. The divergence between human
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …
Chromosome inversions, local adaptation and speciation
We study the evolution of inversions that capture locally adapted alleles when two
populations are exchanging migrants or hybridizing. By suppressing recombination between …
populations are exchanging migrants or hybridizing. By suppressing recombination between …
Complete sequencing of ape genomes
We present haplotype-resolved reference genomes and comparative analyses of six ape
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …
An assessment of the sequence gaps: unfinished business in a finished human genome
Biological research increasingly depends on'finished'genome sequences. Deducing what is
absent from these sequences is not trivial. More than 99% of the euchromatic portion of the …
absent from these sequences is not trivial. More than 99% of the euchromatic portion of the …
The origins and impact of primate segmental duplications
Duplicated sequences are substrates for the emergence of new genes and are an important
source of genetic instability associated with rare and common diseases. Analyses of primate …
source of genetic instability associated with rare and common diseases. Analyses of primate …
A genome-wide survey of structural variation between human and chimpanzee
TL Newman, E Tuzun, VA Morrison… - Genome …, 2005 - genome.cshlp.org
Structural changes (deletions, insertions, and inversions) between human and chimpanzee
genomes have likely had a significant impact on lineage-specific evolution because of their …
genomes have likely had a significant impact on lineage-specific evolution because of their …
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
L Skipper, K Wilkes, M Toft, M Baker, S Lincoln… - The American Journal of …, 2004 - cell.com
The MAPT H1 haplotype has been associated with four-repeat (4R) tauopathies, including
progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease …
progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease …
Is mammalian chromosomal evolution driven by regions of genome fragility?
Background A fundamental question in comparative genomics concerns the identification of
mechanisms that underpin chromosomal change. In an attempt to shed light on the …
mechanisms that underpin chromosomal change. In an attempt to shed light on the …
Comparative primate genomics
▪ Abstract With the completion of the human genome sequence and the advent of
technologies to study functional aspects of genomes, molecular comparisons between …
technologies to study functional aspects of genomes, molecular comparisons between …