If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Signature databases are vital tools for identifying distant relationships in novel sequences
and hence for inferring protein function. InterPro is an integrated documentation resource for …

A variety of nuclear localization signals (NLSs) are experimentally known although only one
motif was available for database searches through PROSITE. We initially collected a set of …

Here we present complete genome sequences, including a comparative analysis, of 103
isolates of foot-and-mouth disease virus (FMDV) representing all seven serotypes and …

Antimicrobial peptides (AMPs) are gaining importance as anti-infective agents. Here we
describe the updated Collection of Antimicrobial Peptide (CAMP) database, available online …

The routing of a fleet of vehicles to service a set of customers is important in the field of
distribution. Vehicle routing problems (VRP) arise in many real-life applications within …

The PROSITE database consists of a large collection of biologically meaningful signatures
that are described as patterns or profiles. Each signature is linked to documentation that …

This paper surveys approaches to the discovery of patterns in biosequences and places
these approaches within a formal framework that systematises the types of patterns and the …

We performed a systematic analysis of gene upstream regions in the yeast genome for
occurrences of regular expression-type patterns with the goal of identifying potential …