HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
Human papillomaviruses: diversity, infection and host interactions
AA McBride - Nature Reviews Microbiology, 2022 - nature.com
Human papillomaviruses (HPVs) are an ancient and highly successful group of viruses that
have co-evolved with their host to replicate in specific anatomical niches of the stratified …
have co-evolved with their host to replicate in specific anatomical niches of the stratified …
Human papillomavirus oncoproteins: pathways to transformation
CA Moody, LA Laimins - Nature reviews cancer, 2010 - nature.com
An association between human papillomavirus (HPV) infection and the development of
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein
degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin …
degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin …
Chasing molecular glue degraders: screening approaches
A Domostegui, L Nieto-Barrado… - Chemical Society …, 2022 - pubs.rsc.org
Protein–protein interactions (PPIs) govern all biological processes. Some small molecules
modulate PPIs through induced protein proximity. In particular, molecular glue degraders …
modulate PPIs through induced protein proximity. In particular, molecular glue degraders …
Ubiquitin-dependent protein degradation
M Hochstrasser - Annual review of genetics, 1996 - annualreviews.org
▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-
associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and …
associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and …
Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade
UBIQUITINATION of proteins involves the concerted action of the El ubiquitin-activating
enzyme, E2 ubiquitin-conjugating enzymes and E3 ubiquitin–protein 1igases1–3. It has …
enzyme, E2 ubiquitin-conjugating enzymes and E3 ubiquitin–protein 1igases1–3. It has …
The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation
Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …