Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

We have investigated the in vivo functional role of rab5, a small GTPase associated with the
plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein …

▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

Small GTPases of the rab family are crucial elements of the machinery that controls
membrane traffic. In the present study, we examined the distribution and function of rab11 …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

The molecular machinery behind lysosome biogenesis and the maintenance of the
perinuclear aggregate of late endocytic structures is not well understood. A likely candidate …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

We have examined the modifications occurring during the transformation of phagosomes
into phagolysosomes in J-774 macrophages. The use of low density latex beads as markers …