Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of
the mineralized extracellular matrices of bones and teeth. OPN is characterized by the …

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To
this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and …

Ovarian cancer is the most common type of gynecologic cancer. One of the leading causes
of high mortality is chemoresistance, developed primarily or during treatment. Different …

In this review most of the various known, suspected, or postulated functions of osteopontin, a
secreted highly acidic phosphoprotein, are discussed in terms of what we currently know …

Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …

Bone sialoprotein (BSP) and osteopontin (OPN) are two members of the SIBLING (S mall I
ntegrin-B inding LI gand, N-linked G lycoprotein) family of genetically related proteins that …

Calcification is common in atheromatous plaques and may contribute to plaque rupture and
subsequent thrombosis. However, little is known about the mechanisms which regulate the …

In an earlier report, we used differential cloning to identify genes that might be critical in
controlling arterial neointima formation (Giachelli, C., N. Bae, D. Lombardi, M. Majesky, and …

At postconfluence, cultured bovine pericytes isolated from retinal capillaries form three‐
dimensional nodule‐like structures that mineralize. Using a combination of Northern and …

Focuses on the molecular and cellular biology of alveolar bone. Formation of
intramembranous bone of the maxilla and mandible from osteoblasts; Similarity of …