Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are
mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

The serotonin (5-HT) hypothesis of schizophrenia arose from early studies on interactions
between the hallucinogenic drug LSD (d-lysergic acid diethylamide) and 5-HT in peripheral …

Light and electron microscope immunocytochemistry with a monoclonal antibody against the
N‐terminal domain of the human protein was used to determine the cellular and subcellular …

Serotonin (5-hydroxytryptamine, 5-HT), the “happy hormone,” has a phylogenetically ancient
role in neural transmission (Turlejski, 1996). Because the serotonergic system has a …

Although treatment-resistant schizophrenia (TRS) was described 50 years ago 1 and has a
gold standard treatment with clozapine based on well-defined criteria, 2 there is still a matter …

The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …

Up to 30% of people with schizophrenia do not respond to two (or more) trials of
dopaminergic antipsychotics. They are said to have treatment-resistant schizophrenia (TRS) …

Importance of the field: Antipsychotic drug is the mainstay of treatment for schizophrenia,
and there are large inter-individual differences in clinical response and side effects …