Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

Parkinson's disease (PD) is a devastating disease associated with accumulation of α-
synuclein (α-Syn) within dopaminergic neurons, leading to neuronal death. PD is …

The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Background Common genetic variance in apolipoprotein E (APOE), β‐glucocerebrosidase
(GBA), microtubule‐associated protein tau (MAPT), and α‐synuclein (SNCA) has been …

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is
associated with poor clinical outcome following traumatic brain injury and other …

The premise of this review is that apolipoprotein (apo) E4 is much more than a contributing
factor to neurodegeneration. ApoE has critical functions in redistributing lipids among CNS …

Alzheimer's disease (AD) is one of the fastest-growing causes of death and disability in
persons 65 years of age or older, affecting more than 5 million Americans alone. Clinical …

Neuroinflammatory processes are known to contribute to the cascade of events culminating
in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's …

Proteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell
death, is one of the most significant pathological features of neurodegenerative diseases …

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …