Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
JC De La Torre - The Lancet Neurology, 2004 - thelancet.com
The cause of Alzheimer's disease (AD) is unknown. This gap in knowledge has created a
stumbling block in the search for a genuinely effective treatment or cure for this dementia …
stumbling block in the search for a genuinely effective treatment or cure for this dementia …
Vascular dysfunction—the disregarded partner of Alzheimer's disease
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …
Hybrid high-order functional connectivity networks using resting-state functional MRI for mild cognitive impairment diagnosis
Conventional functional connectivity (FC), referred to as low-order FC, estimates temporal
correlation of the resting-state functional magnetic resonance imaging (rs-fMRI) time series …
correlation of the resting-state functional magnetic resonance imaging (rs-fMRI) time series …
Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis.
L Bäckman, S Jones, AK Berger, EJ Laukka… - …, 2005 - psycnet.apa.org
To determine the size of the impairment across different cognitive domains in preclinical
Alzheimer's disease (AD), a meta-analysis based on 47 studies involving 9,097 controls and …
Alzheimer's disease (AD), a meta-analysis based on 47 studies involving 9,097 controls and …
Alzheimer disease as a vascular disorder: nosological evidence
JC De la Torre - Stroke, 2002 - Am Heart Assoc
Background—The main stumbling block in the clinical management and in the search for a
cure of Alzheimer disease (AD) is that the cause of this disorder has remained uncertain …
cure of Alzheimer disease (AD) is that the cause of this disorder has remained uncertain …
The Alzheimer's disease β-secretase enzyme, BACE1
SL Cole, R Vassar - Molecular neurodegeneration, 2007 - Springer
The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience
NA Johnson, GH Jahng, MW Weiner, BL Miller… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively determine if pulsed arterial spin-labeling perfusion magnetic
resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer …
resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer …
Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
A high percentage of patients with mild cognitive impairment (MCI) develop clinical
dementia of the Alzheimer type (AD) within 1 year. The aim of this longitudinal study was to …
dementia of the Alzheimer type (AD) within 1 year. The aim of this longitudinal study was to …
Advances in the early detection of Alzheimer's disease
The combination of an aging population and the promise, possibly in the near future, of
disease-modifying therapies have made the characterization of the early stages of …
disease-modifying therapies have made the characterization of the early stages of …