Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Microglia, the main immunocompetent cells of the brain, regulate neuronal function, but their
contribution to cerebral blood flow (CBF) regulation has remained elusive. Here, we identify …

Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Microglia replacement strategies are increasingly being considered for the treatment of
primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and …

Microglia are usually referred to as “the innate immune cells of the brain,”“the resident
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …

Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
develo** embryo but remains ill-defined in humans. We therefore assembled a …

The blood brain barrier (BBB) plays a crucial role in maintaining brain homeostasis by
selectively preventing the entry of substances from the peripheral blood into the central …

Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …