Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pum** throughout the mammal's lifespan. This process is …

ABSTRACT CTCF is a highly conserved zinc-finger DNA-binding protein that mediates
interactions between distant sequences in the genome. As a consequence, CTCF regulates …

The heart is the first organ to be functional in the fetus. Heart formation is a complex
morphogenetic process regulated by both genetic and epigenetic mechanisms. Congenital …

Coordinated chromatin interactions between enhancers and promoters are critical for gene
regulation. The architectural protein CTCF mediates chromatin loo** and is enriched at …

Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved
protein, is known to play a critical role in chromatin structure. Post-translational modifications …

Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells.
These cells, termed cardiomyocytes, display many fascinating behaviors, including complex …

Summary CCCTC-binding factor (CTCF), a ubiquitously expressed architectural protein, has
emerged as a key regulator of cell identity gene transcription. However, the precise …

Studies have suggested a potential role of somatic mitochondrial mutations in cancer
development. To analyze the landscape of somatic mitochondrial mutation in breast cancer …

Developmental dynamics encompass both the specification of cell types and their spatial
organisation into multicellular niches. Here we harness the power of single-cell and spatial …

Properly organizing DNA within the nucleus is critical to ensure normal downstream nuclear
functions. CTCF and cohesin act as major architectural proteins, working in concert to …