Radioimmunotherapy of human tumours
SM Larson, JA Carrasquillo, NKV Cheung… - Nature Reviews …, 2015 - nature.com
The eradication of cancer remains a vexing problem despite recent advances in our
understanding of the molecular basis of neoplasia. One therapeutic approach that has …
understanding of the molecular basis of neoplasia. One therapeutic approach that has …
Radiometals for combined imaging and therapy
CS Cutler, HM Hennkens, N Sisay… - Chemical …, 2013 - ACS Publications
The use of radionuclides in medicine is based largely on the discoveries of two critical
concepts, the “tracer principle” and the “magic bullet”. In 1913, George de Hevesy …
concepts, the “tracer principle” and the “magic bullet”. In 1913, George de Hevesy …
Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance
Antibodies have proven to be effective agents in cancer imaging and therapy. One of the
major challenges still facing the field is the heterogeneous distribution of these agents in …
major challenges still facing the field is the heterogeneous distribution of these agents in …
Development of 225Ac radiopharmaceuticals: TRIUMF perspectives and experiences
Background: The development of radiopharmaceuticals containing 225Ac for targeted alpha
therapy is an active area of academic and commercial research worldwide. Objectives …
therapy is an active area of academic and commercial research worldwide. Objectives …
Tumour targeting with radiometals for diagnosis and therapy
Use of radiometals in nuclear oncology is a rapidly growing field and encompasses a broad
spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT …
spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT …
An overview of targeted alpha therapy
YS Kim, MW Brechbiel - Tumor biology, 2012 - Springer
The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-
particles. Alpha particles are helium nuclei and are~ 8,000 times larger than β−-particles …
particles. Alpha particles are helium nuclei and are~ 8,000 times larger than β−-particles …
Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?
Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation
are locally delivered to tumor cells, while the surrounding healthy tissue is minimally …
are locally delivered to tumor cells, while the surrounding healthy tissue is minimally …
Theranostic terbium radioisotopes: challenges in production for clinical application
N Naskar, S Lahiri - Frontiers in medicine, 2021 - frontiersin.org
Currently, research on terbium has gained a momentum owing to its four short-lived
radioisotopes, 149Tb, 152Tb, 155Tb, and 161Tb, all of which can be considered in one or …
radioisotopes, 149Tb, 152Tb, 155Tb, and 161Tb, all of which can be considered in one or …
Nanoparticles for targeted cancer radiotherapy
Radiotherapy, where ionizing radiation is locally delivered either through an external beam
or by surgically implanting radionuclide-based seeds in the tumor, is one of the gold …
or by surgically implanting radionuclide-based seeds in the tumor, is one of the gold …
Potent candidates for Targeted Auger Therapy: Production and radiochemical considerations
D Filosofov, E Kurakina, V Radchenko - Nuclear Medicine and Biology, 2021 - Elsevier
Abstract Targeted Auger Therapy represents great potential for the therapy of diseases
which require a high degree of selectivity on the cellular level (eg for therapy of metastatic …
which require a high degree of selectivity on the cellular level (eg for therapy of metastatic …