Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory CNS disease that
primarily manifests as relapsing episodes of severe optic neuritis and myelitis. Diagnosis of …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

Introduction Ravulizumab demonstrated efficacy and an acceptable safety profile versus
placebo in the randomized controlled period (RCP) of the phase 3 CHAMPION MG trial in …

This manuscript presents practical recommendations for managing acute attacks and
implementing preventive immunotherapies for neuromyelitis optica spectrum disorders …

Introduction Several patients with myasthenia gravis (MG) do not adequately respond to
available drugs or exhibit poor tolerance, necessitating the need for new therapies. Areas …

Remarkable discoveries over the last two decades have elucidated the autoimmune basis of
several, previously poorly understood, neurological disorders. Autoimmune disorders of the …

Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory
autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most …

Background: Efficacy and safety of inebilizumab for treatment of neuromyelitis optica
spectrum disorder in adults seropositive for aquaporin-4 (AQP4)–immunoglobulin (Ig) G …

Most patients with neuromyelitis optica spectrum disorders (NMOSD) test positive for
aquaporin-4 antibody (AQP4-IgG) or myelin oligodendrocyte glycoprotein antibodies (MOG …

Highlights•This paper presents a comprehensive overview on the efficacy and safety of
eculizumab and its current uses.•Three distinct genetic polymorphisms result in ineffective …