Notch signaling pathway: architecture, disease, and therapeutics
B Zhou, W Lin, Y Long, Y Yang, H Zhang… - Signal transduction and …, 2022 - nature.com
The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
Advances in targeting 'undruggable'transcription factors with small molecules
Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1
Notch has been implicated in human cancers and is a putative therapeutic target. However,
the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore …
the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore …
Roles of notch signaling in the tumor microenvironment
AB D'assoro, R Leon-Ferre, EB Braune… - International journal of …, 2022 - mdpi.com
The Notch signaling pathway is an architecturally simple signaling mechanism, well known
for its role in cell fate regulation during organ development and in tissue homeostasis. In …
for its role in cell fate regulation during organ development and in tissue homeostasis. In …
Recent advances with precision medicine treatment for breast cancer including triple-negative sub-type
Simple Summary The progress of next-generation sequencing technologies has raised
huge expectations for precision-medicine therapy approaches in breast cancer and triple …
huge expectations for precision-medicine therapy approaches in breast cancer and triple …
Notch signalling in healthy and diseased vasculature
F Del Gaudio, D Liu, U Lendahl - Open Biology, 2022 - royalsocietypublishing.org
Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …
Functional analysis of structural variants in single cells using Strand-seq
Somatic structural variants (SVs) are widespread in cancer, but their impact on disease
evolution is understudied due to a lack of methods to directly characterize their functional …
evolution is understudied due to a lack of methods to directly characterize their functional …
Chemoresistance and metastasis in breast cancer molecular mechanisms and novel clinical strategies
Breast cancer is the most common malignant tumor in females worldwide. Chemotherapy is
the standard breast cancer treatment; however, chemoresistance is often seen in patients …
the standard breast cancer treatment; however, chemoresistance is often seen in patients …
Context matters: NOTCH signatures and pathway in cancer progression and metastasis
JO Misiorek, A Przybyszewska-Podstawka, J Kałafut… - Cells, 2021 - mdpi.com
The Notch signaling pathway is a critical player in embryogenesis but also plays various
roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations …
roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations …
Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance
M Feng, RK Santhanam, H **ng, M Zhou… - Biochemical Pharmacology, 2024 - Elsevier
The mechanism of tumor drug resistance is complex and may involve stem cell
maintenance, epithelial-mesenchymal transition, the activation of survival signaling …
maintenance, epithelial-mesenchymal transition, the activation of survival signaling …