Autophagy in healthy aging and disease

Y Aman, T Schmauck-Medina, M Hansen, RI Morimoto… - Nature aging, 2021‏ - nature.com
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Autophagy as a promoter of longevity: insights from model organisms

M Hansen, DC Rubinsztein, DW Walker - Nature reviews Molecular cell …, 2018‏ - nature.com
Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

Emerging roles of ATG7 in human health and disease

JJ Collier, F Suomi, M Oláhová… - EMBO molecular …, 2021‏ - embopress.org
The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

HWS Tan, G Lu, H Dong, YL Cho, A Natalia… - Nature …, 2022‏ - nature.com
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …

Compromised autophagy and neurodegenerative diseases

FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015‏ - nature.com
Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

Autophagy in Huntington disease and huntingtin in autophagy

DDO Martin, S Ladha, DE Ehrnhoefer… - Trends in neurosciences, 2015‏ - cell.com
Autophagy is an important biological process that is essential for the removal of damaged
organelles and toxic or aggregated proteins by delivering them to the lysosome for …

[HTML][HTML] Rare ATG7 genetic variants predispose patients to severe fatty liver disease

GA Baselli, O Jamialahmadi, S Pelusi, E Ciociola… - Journal of …, 2022‏ - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver
disorders and has a strong heritable component. The aim of this study was to identify new …

Neuronal mitophagy in neurodegenerative diseases

M Martinez-Vicente - Frontiers in molecular neuroscience, 2017‏ - frontiersin.org
Neuronal homeostasis depends on the proper functioning of different quality control
systems. All intracellular components are subjected to continuous turnover through the …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015‏ - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases

J Liu, Y **ao, L Cao, S Lu, S Zhang, R Yang… - Communications …, 2024‏ - nature.com
Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis
and is responsible for the quality control of proteins, organelles, and energy metabolism …