Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA

NK Surana, DL Kasper - Immunological reviews, 2012 - Wiley Online Library
Over the past several years, there have been remarkable advances in our understanding of
how commensal organisms shape host immunity. Although the full cast of immunogenic …

Synthetic, zwitterionic Sp1 oligosaccharides adopt a helical structure crucial for antibody interaction

Q Zhang, A Gimeno, D Santana, Z Wang… - ACS central …, 2019 - ACS Publications
The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important
anchor point for our immune system to act against streptococcal infections. Antibodies can …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010

DJ Harvey - Mass spectrometry reviews, 2015 - Wiley Online Library
This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

Recent advances in the synthesis of glycoconjugates for vaccine development

C Colombo, O Pitirollo, L Lay - Molecules, 2018 - mdpi.com
During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune …

Entirely carbohydrate-based vaccines: an emerging field for specific and selective immune responses

S Nishat, PR Andreana - Vaccines, 2016 - mdpi.com
Carbohydrates are regarded as promising targets for vaccine development against
infectious disease because cell surface glycans on many infectious agents are attributed to …

Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit

B Hagen, JHM van Dijk, Q Zhang, HS Overkleeft… - Organic …, 2017 - ACS Publications
The synthesis of the Staphylococcus aureus strain M capsular polysaccharide repeating unit
is reported. A postglycosylation oxidation strategy was utilized for the construction of the α …

Total Synthesis of Zwitterionic Tetrasaccharide Repeating Unit from Bacteroides fragilis ATCC 25285/NCTC 9343 Capsular Polysaccharide PS A1 with Alternating …

P Eradi, S Ghosh, PR Andreana - Organic letters, 2018 - ACS Publications
The tetrasaccharide repeating unit of zwitterionic polysaccharide A1 (PS A1) from
Bacteroides fragilis ATCC 25285/NCTC 9343 has been synthesized using a linear …

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1

B Schumann, K Reppe, P Kaplonek… - ACS central …, 2018 - ACS Publications
Infections with Streptococcus pneumoniae are a major health burden. Glycoconjugate
vaccines based on capsular polysaccharides (CPSs) successfully protect from infection, but …