Understanding the diversity of dynamic structures and functions of DNA and RNA in biology
requires tools that can selectively and intimately probe these biomolecules. Synthetic …

Fluorescent nucleoside analogues (FNAs) are structurally diverse mimics of the natural
essentially non-fluorescent nucleosides which have found numerous applications in probing …

Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

Fluorescence labeling and probing are fundamental techniques for nucleic acid analysis
and quantification. However, new fluorescent probes and approaches are urgently needed …

Mounting evidence supports the presence of biologically relevant G‐quadruplexes in single‐
cell organisms, but the existence of endogenous G‐quadruplex structures in mammalian …

Recent advances in optical bioimaging have prompted the need for minimal chemical
reporters that can retain the molecular recognition properties and activity profiles of …

An enzymatic method has been successfully established enabling the generation of partially
base-modified RNA (previously named RZA) constructs, in which all G residues were …

RNA is a versatile biomolecule with a broad range of biological functions that go far beyond
its initially described role as a simple information carrier. The development of chemical …

Conspectus In 1960, Weber prophesied that “There are many ways in which the properties
of the excited state can be utilized to study points of ignorance of the structure and function …

Base‐modified fluorescent nucleoside analog probes have been very valuable in the study
of nucleic acid structure and function. Many of them structurally resemble natural bases, and …