Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate
skeletal development. FGF signaling regulates development of the limb bud and formation of …

Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays
essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs …

The brain originates relatively early in development from differentiated ectoderm that forms a
hollow tube and takes on an exceedingly complex shape with development. The skull is …

Neural crest cells are a vertebrate-specific migratory, multipotent cell population that give
rise to a diverse array of cells and tissues during development. Cranial neural crest cells, in …

Craniosynostosis is a condition of complex etiology that always involves the premature
fusion of one or multiple cranial sutures and includes various anomalies of the soft and hard …

Skeletal stem cells from the suture mesenchyme, which are referred to as suture stem cells
(SuSCs), exhibit long-term self-renewal, clonal expansion, and multipotency. These SuSCs …

Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the
primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and …

Craniofacial abnormalities often involve sutures, the growth centers of the skull. To
characterize the organization and processes governing their development, we profile the …

Craniosynostosis, a condition that includes the premature fusion of one or multiple cranial
sutures, is a relatively common birth defect in humans and the second most common …

The morphogenesis of midfacial processes requires the coordination of a variety of cellular
functions of both mesenchymal and epithelial cells to develop complex structures. Any …