Medulloblastoma
Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
Medulloblastoma
NE Millard, KC De Braganca - Journal of child neurology, 2016 - journals.sagepub.com
Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur
exclusively in the posterior fossa and have the potential for leptomeningeal spread …
exclusively in the posterior fossa and have the potential for leptomeningeal spread …
Medulloblastoma comprises four distinct molecular variants
Purpose Recent genomic approaches have suggested the existence of multiple distinct
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine …
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine …
Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis
S Rutkowski, K Von Hoff, A Emser, I Zwiener… - Journal of clinical …, 2010 - ascopubs.org
Purpose To assess the prognostic role of clinical parameters and histology in early
childhood medulloblastoma. Patients and Methods Clinical and histologic data from 270 …
childhood medulloblastoma. Patients and Methods Clinical and histologic data from 270 …
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
DW Ellison, M Kocak, J Dalton, H Megahed… - Journal of clinical …, 2011 - ascopubs.org
Purpose Medulloblastomas are heterogeneous and include relatively good-prognosis
tumors characterized by Wnt pathway activation, as well as those that cannot be successfully …
tumors characterized by Wnt pathway activation, as well as those that cannot be successfully …
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease
We undertook a comprehensive clinical and biological investigation of serial
medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family …
medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family …
Childhood medulloblastoma
Abstract Medulloblastoma accounts for 15–20% of childhood nervous system tumours. The
risk of dying was reduced by 30% in the last twenty years. Patients are divided in risk strata …
risk of dying was reduced by 30% in the last twenty years. Patients are divided in risk strata …
Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study
Background Disease relapse occurs in around 30% of children with medulloblastoma, and
is almost universally fatal. We aimed to establish whether the clinical and molecular …
is almost universally fatal. We aimed to establish whether the clinical and molecular …
Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy
C Cacciotti, A Fleming… - The Journal of pathology, 2020 - Wiley Online Library
Central nervous system (CNS) tumors are the most common solid tumor in pediatrics,
accounting for approximately 25% of all childhood cancers, and the second most common …
accounting for approximately 25% of all childhood cancers, and the second most common …
Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic …
This study was designed to confirm the previously observed favorable survival rates and
prognostic factors in young children with nonmetastatic medulloblastoma (MB) treated with …
prognostic factors in young children with nonmetastatic medulloblastoma (MB) treated with …