Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Blood GFAP as an emerging biomarker in brain and spinal cord disorders

A Abdelhak, M Foschi, S Abu-Rumeileh… - Nature Reviews …, 2022 - nature.com
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …

Global, regional and national burden of traumatic brain injury and spinal cord injury, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019

B Guan, DB Anderson, L Chen, S Feng, H Zhou - BMJ open, 2023 - bmjopen.bmj.com
Objectives To evaluate the most up-to-date burden of traumatic brain injury (TBI) and spinal
cord injury (SCI) and analyse their leading causes in different countries/territories. Design …

Multiangle, self-powered sensor array for monitoring head impacts

L Zu, J Wen, S Wang, M Zhang, W Sun, B Chen… - Science …, 2023 - science.org
Mild concussions occur frequently and may come with long-term cognitive, affective, and
physical sequelae. However, the diagnosis of mild concussions lacks objective assessment …

Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

Post-concussion symptoms and disability in adults with mild traumatic brain injury: a systematic review and meta-analysis

C Cancelliere, L Verville, JL Stubbs, H Yu… - Journal of …, 2023 - liebertpub.com
Studies investigating long-term symptoms and disability after mild traumatic brain injury
(mTBI) have yielded mixed results. This systematic review and meta-analysis aimed to …

Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

A manual for the glasgow outcome scale-extended interview

L Wilson, K Boase, LD Nelson, NR Temkin… - Journal of …, 2021 - liebertpub.com
The Glasgow Outcome Scale-Extended (GOSE) has become one of the most widely used
outcome instruments to assess global disability and recovery after traumatic brain injury …

Traumatic brain injury as a chronic disease: insights from the United States traumatic brain injury model systems research program

K Dams-O'Connor, SB Juengst, J Bogner… - The Lancet …, 2023 - thelancet.com
Traumatic brain injury (TBI) is a global health priority, associated with substantial burden.
Historically conceptualised as an injury event with finite recovery, TBI is now recognised as …