Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

The imbalance between production and clearance of amyloid β (Aβ) peptides and their
resulting accumulation in the brain is an early and crucial step in the pathogenesis of …

Aims/hypothesis Beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is required
for the production of toxic amyloid peptides and is highly expressed in the brain, but also to a …

Hoy en día se sabe que el fenómeno de hipoxia, el cual es una disminución del oxígeno a
nivel tisular (Bhutta et al., 2022), puede ser causado por una amplia gama de patologías …