Recent advances in therapeutic strategies for triple-negative breast cancer

Y Li, H Zhang, Y Merkher, L Chen, N Liu… - Journal of hematology & …, 2022 - Springer
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC)
with a poor prognosis. Current treatment options are limited to surgery, adjuvant …

Dynamic EMT: a multi‐tool for tumor progression

S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Distinct contributions of partial and full EMT to breast cancer malignancy

F Lüönd, N Sugiyama, R Bill, L Bornes, C Hager… - Developmental cell, 2021 - cell.com
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …

Overcoming endocrine resistance in breast cancer

AB Hanker, DR Sudhan, CL Arteaga - Cancer cell, 2020 - cell.com
Estrogen receptor-positive (ER+) breast cancer is the most common breast cancer subtype.
Treatment of ER+ breast cancer comprises interventions that suppress estrogen production …

Mechanisms of chemotherapy resistance in triple-negative breast cancer—how we can rise to the challenge

M Nedeljković, A Damjanović - Cells, 2019 - mdpi.com
Triple-negative (TNBC) is the most lethal subtype of breast cancer owing to high
heterogeneity, aggressive nature, and lack of treatment options. Chemotherapy remains the …

Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

AP Deshmukh, SV Vasaikar… - Proceedings of the …, 2021 - National Acad Sciences
The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal
development and in cancer progression. EMT is induced by various signaling pathways …

Controversies around epithelial–mesenchymal plasticity in cancer metastasis

ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Cancer stem cells revisited

E Batlle, H Clevers - Nature medicine, 2017 - nature.com
The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Context-dependent EMT programs in cancer metastasis

NM Aiello, Y Kang - Journal of Experimental Medicine, 2019 - rupress.org
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …

[HTML][HTML] Targeting cancer stemness in the clinic: from hype to hope

C Saygin, D Matei, R Majeti, O Reizes, JD Lathia - Cell stem cell, 2019 - cell.com
Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of
genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining …