Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …

In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype
switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic …

Class-switch DNA recombination (CSR) of the immunoglobulin heavy chain (IGH) locus is
central to the maturation of the antibody response and crucially requires the cytidine …

Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

DNA double-strand breaks (DSBs) are generally accepted to be the most biologically
significant lesion by which ionizing radiation causes cancer and hereditary disease …

Antibody class switching occurs in mature B cells in response to antigen stimulation and
costimulatory signals. It occurs by a unique type of intrachromosomal deletional …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Transcriptional R loops are anomalous RNA: DNA hybrids that have been detected in
organisms from bacteria to humans. These structures have been shown in eukaryotes to …