Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …

Aromatic amino acids: a complex network ripe for future exploration

JH Lynch, N Dudareva - Trends in plant science, 2020 - cell.com
In plants, high carbon flux is committed to the biosynthesis of phenylalanine, tyrosine, and
tryptophan, owing to their roles not only in the production of proteins, but also as precursors …

Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis

XC Wang, J Wu, ML Guan, CH Zhao, P Geng… - The Plant …, 2020 - Wiley Online Library
Flavonoids are major secondary metabolites derived from the plant phenylpropanoid
pathway that play important roles in plant development and also have benefits for human …

The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation

R Yokoyama, MVV de Oliveira, B Kleven… - The Plant …, 2021 - academic.oup.com
The plant shikimate pathway directs bulk carbon flow toward biosynthesis of aromatic amino
acids (AAAs, ie tyrosine, phenylalanine, and tryptophan) and numerous aromatic …

The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism

J Wu, Y Chen, Y Huang, B Hao, S Dai, L Zhao… - Science …, 2024 - science.org
The aromatic amino acids (AAAs) phenylalanine, tyrosine, and tryptophan are basic protein
units and precursors of diverse specialized metabolites that are essential for plant growth …

Coordinated regulation of the entry and exit steps of aromatic amino acid biosynthesis supports the dual lignin pathway in grasses

J El-Azaz, B Moore, Y Takeda-Kimura… - Nature …, 2023 - nature.com
Vascular plants direct large amounts of carbon to produce the aromatic amino acid
phenylalanine to support the production of lignin and other phenylpropanoids. Uniquely …

A phytochrome B-independent pathway restricts growth at high levels of jasmonate defense

IT Major, Q Guo, J Zhai, G Kapali, DM Kramer… - Plant …, 2020 - academic.oup.com
The plant hormone jasmonate (JA) promotes resistance to biotic stress by stimulating the
degradation of JASMONATE ZIM-DOMAIN (JAZ) proteins, which relieves repression on …

Debottlenecking the L-DOPA 4,5-dioxygenase step with enhanced tyrosine supply boosts betalain production in Nicotiana benthamiana

S Jung, HA Maeda - Plant physiology, 2024 - academic.oup.com
Synthetic biology provides emerging tools to produce valuable compounds in plant hosts as
sustainable chemical production platforms. However, little is known about how supply and …

Point mutations that boost aromatic amino acid production and CO2 assimilation in plants

R Yokoyama, MVV de Oliveira, Y Takeda-Kimura… - Science …, 2022 - science.org
Aromatic compounds having unusual stability provide high-value chemicals and
considerable promise for carbon storage. Terrestrial plants can convert atmospheric CO2 …

Harnessing evolutionary diversification of primary metabolism for plant synthetic biology

HA Maeda - Journal of Biological Chemistry, 2019 - ASBMB
Plants produce numerous natural products that are essential to both plant and human
physiology. Recent identification of genes and enzymes involved in their biosynthesis now …