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Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
Decoding the tumor microenvironment with spatial technologies
Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
BANKSY unifies cell ty** and tissue domain segmentation for scalable spatial omics data analysis
Spatial omics data are clustered to define both cell types and tissue domains. We present
Building Aggregates with a Neighborhood Kernel and Spatial Yardstick (BANKSY), an …
Building Aggregates with a Neighborhood Kernel and Spatial Yardstick (BANKSY), an …
CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data
CZI Cell Science Program, S Abdulla… - Nucleic Acids …, 2025 - academic.oup.com
Hundreds of millions of single cells have been analyzed using high-throughput
transcriptomic methods. The cumulative knowledge within these datasets provides an …
transcriptomic methods. The cumulative knowledge within these datasets provides an …
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
The Hippo pathway is a key growth control pathway that is conserved across species. The
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …
downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ …
Doublet identification in single-cell sequencing data using scDblFinder
Doublets are prevalent in single-cell sequencing data and can lead to artifactual findings. A
number of strategies have therefore been proposed to detect them. Building on the strengths …
number of strategies have therefore been proposed to detect them. Building on the strengths …
Intraventricular B7-H3 CAR T cells for diffuse intrinsic pontine glioma: preliminary first-in-human bioactivity and safety
Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding
innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) …
innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) …
[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
Spatial transcriptomics at subspot resolution with BayesSpace
Recent spatial gene expression technologies enable comprehensive measurement of
transcriptomic profiles while retaining spatial context. However, existing analysis methods …
transcriptomic profiles while retaining spatial context. However, existing analysis methods …
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical
challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined …
challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined …