Introduction Influenza is a respiratory infection associated with a significant clinical burden
globally. Adults aged≥ 65 years are at increased risk of severe influenza-related symptoms …

The ongoing COVID-19 pandemic highlights that complications and mortality associated
with infectious diseases increase with age. Various vaccines are recommended for adults …

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …

Two zoonotic influenza A viruses (IAV) of global concern, H5N1 and H7N9, exhibit
unexplained differences in age distribution of human cases. Using data from all known …

Background Statistical modelling studies based on excess morbidity and mortality are
important for understanding RSV disease burden for age groups that are less frequently …

Background Specific treatments for influenza are limited to neuraminidase inhibitors and
adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions …

Objectives The association of current smoking with influenza infection is not widely
recognised. The aim of this systematic review was to summarise published evidence and …

Background The optimal antiviral drug for treatment of severe influenza remains unclear. To
support updated WHO influenza clinical guidelines, this systematic review and network meta …

Background Individuals with comorbidities are at increased risk of severe respiratory
syncytial virus (RSV) infection. We estimated RSV-associated respiratory hospitalization …

Background Respiratory syncytial virus (RSV) is the main cause of infant and child
hospitalizations. The study objective is to estimate the RSV-associated hospitalizations and …