Adult-onset autoimmune diabetes: current knowledge and implications for management

R Buzzetti, S Zampetti, E Maddaloni - Nature Reviews Endocrinology, 2017 - nature.com
Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a
reduced genetic load, a less intensive autoimmune process and a mild metabolic …

Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

S Shao, QQ Xu, X Yu, R Pan, Y Chen - Pharmacology & therapeutics, 2020 - Elsevier
Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs
(OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the …

Management of latent autoimmune diabetes in adults: a consensus statement from an international expert panel

R Buzzetti, T Tuomi, D Mauricio, M Pietropaolo… - Diabetes, 2020 - Am Diabetes Assoc
A substantial proportion of patients with adult-onset diabetes share features of both type 1
diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically …

The time is right for a new classification system for diabetes: rationale and implications of the β-cell–centric classification schema

SS Schwartz, S Epstein, BE Corkey, SFA Grant… - Diabetes …, 2016 - Am Diabetes Assoc
The current classification system presents challenges to the diagnosis and treatment of
patients with diabetes mellitus (DM), in part due to its conflicting and confounding definitions …

Adult-onset autoimmune diabetes

R Buzzetti, E Maddaloni, J Gaglia, RD Leslie… - Nature reviews Disease …, 2022 - nature.com
Adult-onset autoimmune (AOA) diabetes pathophysiology starts with immune changes,
followed by dysglycaemia and overt disease. AOA diabetes can occur as classic type 1 …

Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment

RD Leslie, J Palmer, NC Schloot, A Lernmark - Diabetologia, 2016 - Springer
Diabetes is not a single homogeneous disease but composed of many diseases with
hyperglycaemia as a common feature. Four factors have, historically, been used to identify …

Latent autoimmune diabetes of the adult: current knowledge and uncertainty

E Laugesen, JA Østergaard, RDG Leslie… - Diabetic …, 2015 - Wiley Online Library
Patients with adult‐onset autoimmune diabetes have less Human Leucocyte Antigen (HLA)‐
associated genetic risk and fewer diabetes‐associated autoantibodies compared with …

Latent autoimmune diabetes in adults: current status and new horizons

P Pozzilli, S Pieralice - Endocrinology and Metabolism, 2018 - synapse.koreamed.org
Autoimmune diabetes is a heterogeneous disease which can arise at any age. Subjects with
adult-onset autoimmune diabetes who do not necessitate insulin-therapy for at least 6 …

SGLT inhibitor adjunct therapy in type 1 diabetes

RJ McCrimmon, RR Henry - Diabetologia, 2018 - Springer
Non-insulin adjunct therapies in type 1 diabetes have been proposed as a means of
improving glycaemic control and reducing risk of hypoglycaemia. Evidence to support this …

Ten years of experience with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus

G Sesti, A Avogaro, S Belcastro, BM Bonora, M Croci… - Acta …, 2019 - Springer
Achieving and maintaining recommended glycemic targets without causing adverse e ffects,
including hypoglycemia, is challenging, especially in older patients with type 2 diabetes …