Mitochondrial ROS formation in the pathogenesis of diabetic cardiomyopathy

N Kaludercic, F Di Lisa - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …

Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy

NJ Byrne, NS Rajasekaran, ED Abel… - Free Radical Biology and …, 2021 - Elsevier
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Molecular mechanisms of diabetic cardiomyopathy

H Bugger, ED Abel - Diabetologia, 2014 - Springer
In recent years, diabetes mellitus has become an epidemic and now represents one of the
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …

Diabetic cardiomyopathy and its mechanisms: role of oxidative stress and damage

Q Liu, S Wang, L Cai - Journal of diabetes investigation, 2014 - Wiley Online Library
Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence
of vascular diseases. The exact mechanisms underlying the disease remain incompletely …

Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment

I Falcão-Pires, AF Leite-Moreira - Heart failure reviews, 2012 - Springer
Diabetes mellitus is an important and prevalent risk factor for congestive heart failure.
Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic …

Rodent models of diabetic cardiomyopathy

H Bugger, ED Abel - Disease models & mechanisms, 2009 - journals.biologists.com
Diabetic cardiomyopathy increases the risk of heart failure in individuals with diabetes,
independently of co-existing coronary artery disease and hypertension. The underlying …

CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis

L Chen, Z Yin, X Qin, X Zhu, X Chen, G Ding… - Pharmacological …, 2022 - Elsevier
Type 2 diabetes mellitus (T2D) contributes to sustained inflammation and myopathic
changes in the heart although the precise interplay between the two remains largely …

NADPH oxidases in heart failure: poachers or gamekeepers?

M Zhang, A Perino, A Ghigo, E Hirsch… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …

Diabetic cardiomyopathy

O Asghar, A Al-Sunni, K Khavandi, A Khavandi… - Clinical …, 2009 - portlandpress.com
Diabetic cardiomyopathy is a distinct primary disease process, independent of coronary
artery disease, which leads to heart failure in diabetic patients. Epidemiological and clinical …

Heat stress induced apoptosis is triggered by transcription-independent p53, Ca2+ dyshomeostasis and the subsequent Bax mitochondrial translocation

ZT Gu, L Li, F Wu, P Zhao, H Yang, YS Liu, Y Geng… - Scientific reports, 2015 - nature.com
In this study, We demonstrated that Bax mitochondrial translocation plays a vital role in the
initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition …