Mitochondrial ROS formation in the pathogenesis of diabetic cardiomyopathy
N Kaludercic, F Di Lisa - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …
may increase the risk for heart failure development. This risk evolves from functional and …
Molecular mechanisms of diabetic cardiomyopathy
In recent years, diabetes mellitus has become an epidemic and now represents one of the
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …
most prevalent disorders. Cardiovascular complications are the major cause of mortality and …
Diabetic cardiomyopathy and its mechanisms: role of oxidative stress and damage
Q Liu, S Wang, L Cai - Journal of diabetes investigation, 2014 - Wiley Online Library
Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence
of vascular diseases. The exact mechanisms underlying the disease remain incompletely …
of vascular diseases. The exact mechanisms underlying the disease remain incompletely …
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment
Diabetes mellitus is an important and prevalent risk factor for congestive heart failure.
Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic …
Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic …
Rodent models of diabetic cardiomyopathy
Diabetic cardiomyopathy increases the risk of heart failure in individuals with diabetes,
independently of co-existing coronary artery disease and hypertension. The underlying …
independently of co-existing coronary artery disease and hypertension. The underlying …
CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis
L Chen, Z Yin, X Qin, X Zhu, X Chen, G Ding… - Pharmacological …, 2022 - Elsevier
Type 2 diabetes mellitus (T2D) contributes to sustained inflammation and myopathic
changes in the heart although the precise interplay between the two remains largely …
changes in the heart although the precise interplay between the two remains largely …
NADPH oxidases in heart failure: poachers or gamekeepers?
M Zhang, A Perino, A Ghigo, E Hirsch… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Oxidative stress is involved in the pathogenesis of heart failure but clinical
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …
antioxidant trials have been unsuccessful. This may be because effects of reactive oxygen …
Diabetic cardiomyopathy
O Asghar, A Al-Sunni, K Khavandi, A Khavandi… - Clinical …, 2009 - portlandpress.com
Diabetic cardiomyopathy is a distinct primary disease process, independent of coronary
artery disease, which leads to heart failure in diabetic patients. Epidemiological and clinical …
artery disease, which leads to heart failure in diabetic patients. Epidemiological and clinical …
Heat stress induced apoptosis is triggered by transcription-independent p53, Ca2+ dyshomeostasis and the subsequent Bax mitochondrial translocation
ZT Gu, L Li, F Wu, P Zhao, H Yang, YS Liu, Y Geng… - Scientific reports, 2015 - nature.com
In this study, We demonstrated that Bax mitochondrial translocation plays a vital role in the
initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition …
initiation of the mitochondrial signaling pathway upon activation by heat stress. In addition …