EASL clinical practice guidelines: management of hepatocellular carcinoma

PR Galle, A Forner, JM Llovet, V Mazzaferro… - Journal of …, 2018 - Elsevier
Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-
related death globally. Hepatocellular carcinoma represents about 90% of primary liver …

Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind …

AX Zhu, YK Kang, CJ Yen, RS Finn, PR Galle… - The lancet …, 2019 - thelancet.com
Background Patients with advanced hepatocellular carcinoma and increased α-fetoprotein
concentrations have poor prognosis. We aimed to establish the efficacy of ramucirumab in …

Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification

S Chidambaranathan-Reghupaty, PB Fisher… - Advances in cancer …, 2021 - Elsevier
Hepatocellular carcinoma (HCC), the primary malignancy of hepatocytes, is a diagnosis with
bleak outcome. According to National Cancer Institute's SEER database, the average five …

Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications

TKW Lee, XY Guan, S Ma - Nature reviews Gastroenterology & …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma

European Association For The Study Of … - Journal of …, 2012 - journal-of-hepatology.eu
EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular
carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies …

Liver cancer cell of origin, molecular class, and effects on patient prognosis

D Sia, A Villanueva, SL Friedman, JM Llovet - Gastroenterology, 2017 - Elsevier
Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

Genetic landscape and biomarkers of hepatocellular carcinoma

J Zucman-Rossi, A Villanueva, JC Nault, JM Llovet - Gastroenterology, 2015 - Elsevier
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Deep learning–based multi-omics integration robustly predicts survival in liver cancer

K Chaudhary, OB Poirion, L Lu, LX Garmire - Clinical Cancer Research, 2018 - AACR
Identifying robust survival subgroups of hepatocellular carcinoma (HCC) will significantly
improve patient care. Currently, endeavor of integrating multi-omics data to explicitly predict …