Abstract The American Cancer Society estimated around 61,090 new cases of leukemia
were diagnosed, and around 23,660 people died from this disease in the United States …

Cancer stem cells (CSCs) drive tumor initiation, progression, and therapeutic resistance due
to their self-renewal and differentiation capabilities. Despite encouraging progress in cancer …

Cellular metabolism is a flexible and plastic network that often dictates physiological and
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …

Introduction The therapeutic targeting of the ubiquitin-proteasome pathway (UPP) through
inhibitors of the 20S proteasome core proteolytic activities has revolutionized the treatment …

Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …

Abstract YTH domain family 2 (YTHDF2) is the first identified N6‐methyladenosine (m6A)
reader that regulates the status of mRNA. It has been reported that overexpressed YTHDF2 …

Type II topoisomerases (TOP2) form transient TOP2 cleavage complexes (TOP2ccs) during
their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA …

The proteasome is the main complex responsible for maintaining intracellular protein
homeostasis, impairment of which is associated with cardiac ischaemia/reperfusion (I/R) …

Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults
and are invariably associated with a dismal outcome. These highly malignant tumors share …

Intestinal ischemia/reperfusion (I/R) injury is a typical pathological course in the clinic with a
high morbidity rate. Recent research has pointed out the critical role of ubiquitination during …