Most human genes encode multiple mRNA variants and protein products through alternative
splicing of exons and introns during pre-mRNA processing. In this way, alternative splicing …

Cancer has become a global problem. On all continents, a great number of people are
diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal …

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …

Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive
mechanism by which a residual cell subpopulation accelerates tumor progression. Here, we …

Activation of the PTEN–PI3K–mTORC1 pathway consolidates metabolic programs that
sustain cancer cell growth and proliferation,. Here we show that mechanistic target of …

The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the
detailed mechanism is unclear. In this study, we investigated the interactive effects of p53 …

Prostate cancer (PC) is one of the leading causes of death in males. Available treatments
often lead to the appearance of chemoresistant foci and metastases, with mechanisms still …

A major proportion of extracellular RNAs (exRNAs) do not copurify with extracellular vesicles
(EVs) and remain in ultracentrifugation supernatants of cell-conditioned medium or …

Objectives Prostate cancer, after the phase of androgen dependence, may progress to the
castration‐resistant prostate cancer (CRPC) stage, with resistance to standard therapies …

Autophagy and RNA alternative splicing are two evolutionarily conserved processes
involved in overlap** physiological and pathological processes. However, the extent of …