Reinventing radiobiology in the light of FLASH radiotherapy
CL Limoli, MC Vozenin - Annual Review of Cancer Biology, 2023 - annualreviews.org
Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …
treatment modality that holds the promise of expanding the therapeutic index for nearly any …
FLASH: New intersection of physics, chemistry, biology, and cancer medicine
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …
innovations over the past decade in the field of radiation oncology, with the potential to …
[HTML][HTML] Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
Potential molecular mechanisms behind the ultra-high dose rate “FLASH” effect
E Bogaerts, E Macaeva, S Isebaert… - International Journal of …, 2022 - mdpi.com
FLASH radiotherapy, or the delivery of a dose at an ultra-high dose rate (> 40 Gy/s), has
recently emerged as a promising tool to enhance the therapeutic index in cancer treatment …
recently emerged as a promising tool to enhance the therapeutic index in cancer treatment …
The current status of FLASH particle therapy: a systematic review
Particle therapies are becoming increasingly available clinically due to their beneficial
energy deposition profile, sparing healthy tissues. This may be further promoted with ultra …
energy deposition profile, sparing healthy tissues. This may be further promoted with ultra …
Current views on mechanisms of the FLASH effect in cancer radiotherapy
ABSTRACT FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy that delivers
doses with ultra-high dose rates. The FLASH effect was defined as the ability of FLASH-RT …
doses with ultra-high dose rates. The FLASH effect was defined as the ability of FLASH-RT …
Comet assay profiling of FLASH-induced damage: mechanistic insights into the effects of FLASH irradiation
Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose
rate 'FLASH'irradiation in vivo, with an associated reduction in damage burden being …
rate 'FLASH'irradiation in vivo, with an associated reduction in damage burden being …
FLASH radiotherapy: mechanisms of biological effects and the therapeutic potential in cancer
O Yan, S Wang, Q Wang, X Wang - Biomolecules, 2024 - mdpi.com
Radiotherapy is an important treatment for many unresectable advanced malignant tumors,
and radiotherapy-associated inflammatory reactions to radiation and other toxic side effects …
and radiotherapy-associated inflammatory reactions to radiation and other toxic side effects …
Time‐resolved dose rate measurements in pencil beam scanning proton FLASH therapy with a fiber‐coupled scintillator detector system
E Kanouta, PR Poulsen, G Kertzscher… - Medical …, 2023 - Wiley Online Library
Background The spatial and temporal dose rate distribution of pencil beam scanning (PBS)
proton therapy is important in ultra‐high dose rate (UHDR) or FLASH irradiations. Validation …
proton therapy is important in ultra‐high dose rate (UHDR) or FLASH irradiations. Validation …
FLASH radiotherapy: A new milestone in the field of cancer radiotherapy
R Tang, J Yin, Y Liu, J Xue - Cancer Letters, 2024 - Elsevier
Radiotherapy plays a pivotal role in the control and eradication of tumors, but it can also
induce radiation injury to surrounding normal tissues while targeting tumor cells. In recent …
induce radiation injury to surrounding normal tissues while targeting tumor cells. In recent …