Regulated cell death (RCD) in cancer: key pathways and targeted therapies
F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …
form of cell death that can be regulated by a variety of biomacromolecules, which is …
Heme oxgenase-1, a cardinal modulator of regulated cell death and inflammation
SW Ryter - Cells, 2021 - mdpi.com
Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …
Necroptosis: a novel pathway in neuroinflammation
Z Yu, N Jiang, W Su, Y Zhuo - Frontiers in pharmacology, 2021 - frontiersin.org
Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …
Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine
As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …
Necroptosis in immuno-oncology and cancer immunotherapy
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …
Insight into crosstalk between ferroptosis and necroptosis: novel therapeutics in ischemic stroke
Y Zhou, J Liao, Z Mei, X Liu, J Ge - Oxidative Medicine and …, 2021 - Wiley Online Library
Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …
Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …
Mechanism of resveratrol-induced programmed cell death and new drug discovery against cancer: a review
JY Jang, E Im, ND Kim - International journal of molecular sciences, 2022 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene), a polyphenol found in grapes, red wine,
peanuts, and apples, has been reported to exhibit a wide range of biological and …
peanuts, and apples, has been reported to exhibit a wide range of biological and …
[HTML][HTML] Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver
S Li, R Liu, S **a, G Wei, M Ishfaq, Y Zhang… - … and environmental safety, 2022 - Elsevier
This study set out to assess the mitigative effects of curcumin on AFB1-induced necroptosis
and inflammation in chicken liver. Ninety-six one-day-old AA broiler chickens were …
and inflammation in chicken liver. Ninety-six one-day-old AA broiler chickens were …
Research trends, hot spots and prospects for necroptosis in the field of neuroscience
WT Yan, S Lu, YD Yang, WY Ning, Y Cai… - Neural regeneration …, 2021 - journals.lww.com
There are two types of cell death-apoptosis and necrosis. Apoptosis is cell death regulated
by cell signaling pathways, while necrosis has until recently been considered a passive …
by cell signaling pathways, while necrosis has until recently been considered a passive …