Low back pain (LBP), a prevalent and costly disease around the world, is predominantly
caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial …

Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and
radicular pain. IVD degeneration is characterized by increases in levels of the …

Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

The intervertebral disc is an important mechanical structure that allows range of motion of
the spinal column. Degeneration of the intervertebral disc, incited by aging, traumatic insult …

Understanding the molecular mechanisms regulating the maintenance and destruction of
intervertebral disc may lead to the development of new therapies for intervertebral disc …

Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …

The healthy intervertebral disc (IVD) fulfils the essential function of load absorption, while
maintaining multi-axial flexibility of the spine. The interrelated tissues of the IVD, the annulus …

Intervertebral discs (IVDs) are complex structures that consist of three parts, namely, nucleus
pulposus, annulus fibrosus and cartilage endplates. With aging, IVDs gradually degenerate …

Introduction Oxidative stress has been reported to be involved in numerous human
diseases, including musculoskeletal disorders such as osteoarthritis. However, the …

Intervertebral disc (IVD) degeneration (IDD) is one of the major causes of back pain, a
condition that represents a serious socio-economic burden. Deeper knowledge of the …