Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Progress in Nucleic Acid Research Copyright 2004, Elsevier Inc. and Molecular Biology, Vol.
78 227 All rights reserved. 0079-6603/04 $35.00 modeling. Its modification by ubiquitin …

A remarkably large collection of evolutionarily conserved proteins has been implicated in
processing of noncoding RNAs and biogenesis of ribonucleoproteins. To better define the …

Sequential events in macromolecular biosynthesis are often elegantly coordinated. The
small ribosomal subunit (SSU) processome is a large ribonucleoprotein (RNP) required for …

The small subunit (SSU) processome is a 2.2‐MDa ribonucleoprotein complex involved in
the processing, assembly, and maturation of the SSU of eukaryotic ribosomes. The identities …

▪ Abstract Cells have high-fidelity polymerases whose task is to accurately replicate the
genome, and low-fidelity polymerases with specialized functions. Although some of these …

DNA double strand breaks (DSBs) can be rejoined directly by the nonhomologous end-
joining (NHEJ) pathway of repair. Nucleases and polymerases are required to promote …

The functioning of the eukaryotic genome depends on efficient and accurate DNA replication
and repair. The process of replication is complicated by the ongoing decomposition of DNA …

Ribosomes, the large RNPs that translate mRNA into protein in the cytoplasm of eukaryotic
cells, are synthesized in a subcompartment of the nucleus, the nucleolus. There …

Terminal balls detected at the 5′-end of nascent ribosomal transcripts act as pre-rRNA
processing complexes and are detected in all eukaryotes examined, resulting in illustrious …