Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT
pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in
the development of lipid dense plaques. Chronic inflammation induced by Western-type diet …

Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate
corepressor proteins into specific transcriptional repression complexes that target HDAC …

Various chemical modifications on histones and regions of associated DNA play crucial
roles in genome management by binding specific factors that, in turn, serve to alter the …

Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …

Summary Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …