The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

Based upon case reports and small case series, it has been known for many years that
some types and subtypes of inherited epidermolysis bullosa (EB) may be at risk for …

Simple Summary MMP-13 is an enzyme that can digest and disrupt the tissue structures
surrounding epithelial cells that line the surface of many internal organs, as well as the …

Laminin-5 (Ln-5) is an extracellular matrix substrate for cell adhesion and migration, which is
found in many epithelial basement membranes. Mechanisms eliciting migration on Ln-5 …

Laminins are a family of trimeric glycoproteins present in the extracellular matrix and the
major constituents of basement membranes. Integrins are αβ transmembrane receptors that …

The integrin heterodimer a6134 is expressed in many epithelia and in Schwann cells. In
stratified epithelia, et6134 couple with BPAGI-e and BPAG2 to form hemidesmosomes …

BPAG1 is the major antigenic determinant of autoimmune sera of buIIous pemphigoid (BP)
patients. It is made by stratified squamous epithelia, where it localizes to the inner surface of …

Extracellular matrix proteins and their cellular receptors, integrins, play a fundamental role in
keratinocyte adhesion and migration. During wound healing, keratinocytes detach, migrate …

Integrins α3β1 and α6β4 are abundant receptors on keratinocytes for laminin-5, a major
component of the basement membrane between the epidermis and the dermis in skin …

The molecular mechanism underlying the promotion of wound healing by TGF-beta 1 is
incompletely understood. We report that TGF-beta 1 regulates the regenerative/migratory …