Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
3D lung tissue models for studies on SARS-CoV-2 pathophysiology and therapeutics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …
Physiology assays in human kidney organoids
BS Freedman - American Journal of Physiology-Renal …, 2022 - journals.physiology.org
Kidney organoids derived from human pluripotent stem cells constitute a novel model of
disease, development, and regenerative therapy. Organoids are human, experimentally …
disease, development, and regenerative therapy. Organoids are human, experimentally …
[HTML][HTML] Secretome analysis using Affinity Proteomics and Immunoassays: a focus on Tumor Biology
VM Beutgen, V Shinkevich, J Pörschke… - Molecular & Cellular …, 2024 - Elsevier
The study of the cellular secretome using proteomic techniques continues to capture the
attention of the research community across a broad range of topics in biomedical research …
attention of the research community across a broad range of topics in biomedical research …
Kidney organoid research: current status and applications
O Trush, M Takasato - Current Opinion in Genetics & Development, 2022 - Elsevier
Organoids are being widely introduced as novel research models in multiple research fields.
Human-induced pluripotent stem cells-derived kidney organoids became an indispensable …
Human-induced pluripotent stem cells-derived kidney organoids became an indispensable …
Revealing the clinical potential of high-resolution organoids
The symbiotic interplay of organoid technology and advanced imaging strategies yields
innovative breakthroughs in research and clinical applications. Organoids, intricate three …
innovative breakthroughs in research and clinical applications. Organoids, intricate three …
Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection
JM Vanslambrouck, JA Neil, R Rudraraju… - Journal of …, 2024 - Am Soc Microbiol
With a high incidence of acute kidney injury among hospitalized COVID-19 patients,
considerable attention has been focussed on whether SARS-CoV-2 specifically targets …
considerable attention has been focussed on whether SARS-CoV-2 specifically targets …