Crystal nucleation in liquids: Open questions and future challenges in molecular dynamics simulations

GC Sosso, J Chen, SJ Cox, M Fitzner… - Chemical …, 2016 - ACS Publications
The nucleation of crystals in liquids is one of nature's most ubiquitous phenomena, playing
an important role in areas such as climate change and the production of drugs. As the early …

Nucleation of organic crystals—a molecular perspective

RJ Davey, SLM Schroeder… - Angewandte Chemie …, 2013 - Wiley Online Library
The outcome of synthetic procedures for crystalline organic materials strongly depends on
the first steps along the molecular self‐assembly pathway, a process we know as crystal …

A review of gas hydrate nucleation theories and growth models

W Ke, TM Svartaas, D Chen - Journal of Natural Gas Science and …, 2019 - Elsevier
In this Review, we present a comprehensive overview of fundamental gas hydrate properties
and formation theories. Key terminologies, theories and hypotheses for hydrate nucleation …

Crystal nucleation kinetics from induction times and metastable zone widths

SA Kulkarni, SS Kadam, H Meekes… - Crystal growth & …, 2013 - ACS Publications
We compare two recently developed methods to determine crystal nucleation rates in stirred
solutions by using isonicotinamide (INA) in ethanol as an example. The two developed …

Role of additives in crystal nucleation from solutions: a review

S Xu, D Cao, Y Liu, Y Wang - Crystal Growth & Design, 2021 - ACS Publications
Nucleation is a key step in the crystallization of solution. For regulating and controlling this
process, it is thus critical to understand the nucleation mechanism under different …

Reactive crystallization: a review

MA McDonald, H Salami, PR Harris… - Reaction chemistry & …, 2021 - pubs.rsc.org
Reactive crystallization is not new, but there has been recent growth in its use as a means of
improving performance and sustainability of industrial processes. This review examines …

A review of experimental methods for nucleation rate determination in large-volume batch and microfluidic crystallization

C Devos, T Van Gerven, S Kuhn - Crystal growth & design, 2021 - ACS Publications
Determination of the experimental nucleation rate for crystallization in solution has been
acknowledged as an important topic for a long time, as it improves the design and control of …

Measuring induction times and crystal nucleation rates

C Brandel, JH ter Horst - Faraday discussions, 2015 - pubs.rsc.org
A large variation is observed in induction times measured under equal conditions in 1 ml
solutions. Ruling out experimental errors, this variation originates from the nucleation …

Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations

CJ Brown, T McGlone, S Yerdelen… - … Systems Design & …, 2018 - pubs.rsc.org
Continuous manufacturing is widely used for the production of commodity products.
Currently, it is attracting increasing interest from the pharmaceutical industry and regulatory …

Crystal population balance formulation and solution methods: a review

HM Omar, S Rohani - Crystal Growth & Design, 2017 - ACS Publications
Crystallization is an important part of many chemical industries. Efforts are being invested to
improve the performance of the crystallization process by designing novel crystallizers. An …