Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …

The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to
initiate heterogeneous tumors. It is also relevant in metastasis and can explain how …

Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell
populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to …

Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Adopting a systems approach, we devise a general workflow to define actionable subtypes
in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four …

Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has
been extensively studied to address the unresolved variable treatment response across …

Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states
during epithelial–mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often …

Simple Summary Epithelial-mesenchymal transition (EMT) is a key process in cancer
progression through which cells weaken their cell-cell adhesion and gain mobility and …

Therapies that prevent metastatic dissemination and tumor growth in secondary organs are
severely lacking. A better understanding of the mechanisms that drive metastasis will lead to …