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Impaired dopamine release in Parkinson's disease
Parkinson's disease is the second most common neurodegenerative disease and yet the
early pathophysiological events of the condition and sequences of dysfunction remain …
early pathophysiological events of the condition and sequences of dysfunction remain …
Protein transmission in neurodegenerative disease
Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
Modeling Parkinson's disease with the alpha-synuclein protein
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
Activation of microglia by classical inflammatory mediators can convert astrocytes into a
neurotoxic A1 phenotype in a variety of neurological diseases,. Development of agents that …
neurotoxic A1 phenotype in a variety of neurological diseases,. Development of agents that …
Animal models of Parkinson's disease: Bridging the gap between disease hallmarks and research questions
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
Microglia maintain homeostasis in the central nervous system through phagocytic clearance
of protein aggregates and cellular debris. This function deteriorates during ageing and …
of protein aggregates and cellular debris. This function deteriorates during ageing and …
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer's and
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …
Hierarchical materials from high information content macromolecular building blocks: Construction, dynamic interventions, and prediction
Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature.
Because hierarchy gives rise to unique properties and functions, many have sought …
Because hierarchy gives rise to unique properties and functions, many have sought …
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Background Converging evidence suggests a role for microglia-mediated
neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a …
neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a …
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …