Flavin dependent monooxygenases

MME Huijbers, S Montersino, AH Westphal… - Archives of biochemistry …, 2014 - Elsevier
Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …

[HTML][HTML] Oxidation and reduction of actin: Origin, impact in vitro and functional consequences in vivo

C Rouyère, T Serrano, S Frémont, A Echard - European journal of cell …, 2022 - Elsevier
Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

Direct redox regulation of F-actin assembly and disassembly by Mical

RJ Hung, CW Pak, JR Terman - Science, 2011 - science.org
Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Metastasis: cancer cell's escape from oxidative stress

G Pani, T Galeotti, P Chiarugi - Cancer and Metastasis Reviews, 2010 - Springer
According to a “canonical” view, reactive oxygen species (ROS) positively contribute, in
different ways, to carcinogenesis and to malignant progression of tumor cells: they drive …

MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics

S Rajan, JR Terman, E Reisler - Frontiers in cell and developmental …, 2023 - frontiersin.org
Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …

Oxidation of F-actin controls the terminal steps of cytokinesis

S Frémont, H Hammich, J Bai, H Wioland… - Nature …, 2017 - nature.com
Cytokinetic abscission, the terminal step of cell division, crucially depends on the local
constriction of ESCRT-III helices after cytoskeleton disassembly. While the microtubules of …

Glucocorticoids, genes and brain function

GR Juszczak, AM Stankiewicz - Progress in Neuro-Psychopharmacology …, 2018 - Elsevier
The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Mical links semaphorins to F-actin disassembly

RJ Hung, U Yazdani, J Yoon, H Wu, T Yang, N Gupta… - Nature, 2010 - nature.com
How instructive cues present on the cell surface have their precise effects on the actin
cytoskeleton is poorly understood. Semaphorins are one of the largest families of these …

Toward rational protein crystallization: A Web server for the design of crystallizable protein variants

L Goldschmidt, DR Cooper, ZS Derewenda… - Protein …, 2007 - Wiley Online Library
Growing well‐diffracting crystals constitutes a serious bottleneck in structural biology. A
recently proposed crystallization methodology for “stubborn crystallizers” is to engineer …

Oxidants in physiological processes

UG Knaus - Reactive oxygen species: Network pharmacology and …, 2021 - Springer
A number of diseases and conditions have been associated with prolonged or persistent
exposure to non-physiological levels of reactive oxygen species (ROS). Similarly, ROS …