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Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
L Qian, Y Zhu, C Deng, Z Liang, J Chen… - Signal transduction and …, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
PGC-1α as a pivotal factor in lipid and metabolic regulation
Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …
Lactic acid in macrophage polarization: the significant role in inflammation and cancer
H Zhou, XY Yan, W Yu, X Liang, X Du… - International reviews …, 2022 - Taylor & Francis
Metabolite lactic acid has always been regarded as a metabolic by-product rather than a
bioactive molecule. Recently, this view has changed since it was discovered that lactic acid …
bioactive molecule. Recently, this view has changed since it was discovered that lactic acid …
Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?
Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …
Hypoxia in breast cancer—scientific translation to therapeutic and diagnostic clinical applications
Y Zhang, H Zhang, M Wang, T Schmid, Z **n… - Frontiers in …, 2021 - frontiersin.org
Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral
hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is …
hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is …
CRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway
Y **, S Bian, H Wang, J Mo, H Fei, L Li, T Chen… - Cell Death & …, 2022 - nature.com
As the predominant stroma cells of tumor microenvironment (TME), cancer associated
fibroblasts (CAFs) are robust tumor player of different malignancies. However, less is known …
fibroblasts (CAFs) are robust tumor player of different malignancies. However, less is known …
PGC1α: friend or foe in cancer?
F Mastropasqua, G Girolimetti, M Shoshan - Genes, 2018 - mdpi.com
The PGC1 family (Peroxisome proliferator-activated receptor γ (PPARγ) coactivators) of
transcriptional coactivators are considered master regulators of mitochondrial biogenesis …
transcriptional coactivators are considered master regulators of mitochondrial biogenesis …
PI3K/AKT signaling activates HIF1α to modulate the biological effects of invasive breast cancer with microcalcification
Y Tian, L Zhao, Z Gui, S Liu, C Liu, T Yu, L Zhang - NPJ breast cancer, 2023 - nature.com
Microcalcification (MC) is a valuable diagnostic indicator of breast cancer, and it is reported
to be associated with increased tumor aggressiveness and poor prognosis. Nevertheless …
to be associated with increased tumor aggressiveness and poor prognosis. Nevertheless …
Hypoxia inducible factor-1α (HIF-1α) in breast cancer: The crosstalk with oncogenic and onco-suppressor factors in regulation of cancer hallmarks
Low oxygen level at tumor microenvironment leads to a condition, known as hypoxia that is
implicated in cancer progression. Upon hypoxia, HIF-1α undergoes activation and due to its …
implicated in cancer progression. Upon hypoxia, HIF-1α undergoes activation and due to its …
Extracellular matrix signals as drivers of mitochondrial bioenergetics and metabolic plasticity of cancer cells during metastasis
The role of metabolism in tumor growth and chemoresistance has received considerable
attention, however, the contribution of mitochondrial bioenergetics in migration, invasion …
attention, however, the contribution of mitochondrial bioenergetics in migration, invasion …