Rodent models of post-traumatic stress disorder: behavioral assessment

A Verbitsky, D Dopfel, N Zhang - Translational psychiatry, 2020 - nature.com
Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …

Posttraumatic stress disorder and cardiovascular disease: state of the science, knowledge gaps, and research opportunities

CJ O'Donnell, LS Longacre, BE Cohen… - JAMA …, 2021 - jamanetwork.com
Posttraumatic stress disorder (PTSD) is characterized by a persistent maladaptive reaction
after exposure to severe psychological trauma. Traumatic events that may precipitate PTSD …

Animal models of PTSD: a challenge to be met

G Richter-Levin, O Stork, MV Schmidt - Molecular psychiatry, 2019 - nature.com
Recent years have seen increased interest in psychopathologies related to trauma
exposure. Specifically, there has been a growing awareness to posttraumatic stress disorder …

The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions

BW Dunlop, A Wong - Progress in Neuro-psychopharmacology and …, 2019 - Elsevier
Questions of how altered functioning of the hypothalamic pituitary adrenal (HPA) axis
contribute to the development and maintenance of posttraumatic stress disorder (PTSD) …

The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research

TCM Bienvenu, C Dejean, D Jercog, B Aouizerate… - Neuron, 2021 - cell.com
Translational research on post-traumatic stress disorder (PTSD) has produced limited
improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal …

Sleep in the United States military

CH Good, AJ Brager, VF Capaldi… - …, 2020 - nature.com
The military lifestyle often includes continuous operations whether in training or deployed
environments. These stressful environments present unique challenges for service members …

Laboratory models of post-traumatic stress disorder: The elusive bridge to translation

JE Dunsmoor, JM Cisler, GA Fonzo, SK Creech… - Neuron, 2022 - cell.com
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …

Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders

E Doney, A Cadoret, L Dion‐Albert… - European Journal of …, 2022 - Wiley Online Library
Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

Metabolism, metabolomics, and inflammation in posttraumatic stress disorder

SH Mellon, A Gautam, R Hammamieh, M Jett… - Biological …, 2018 - Elsevier
Posttraumatic stress disorder (PTSD) is defined by classic psychological manifestations,
although among the characteristics are significantly increased rates of serious somatic …

Ecology and neurobiology of fear in free-living wildlife

LY Zanette, M Clinchy - Annual Review of Ecology, Evolution …, 2020 - annualreviews.org
The ecology of fear concerns the population-, community-, and ecosystem-level
consequences of the behavioral interactions between predators and prey, ie, the aggregate …