Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies
Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Pathogenesis and virulence of herpes simplex virus
S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
The roles of histone variants in fine-tuning chromatin organization and function
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Classification of adult‐type diffuse gliomas: Impact of the World Health Organization 2021 update
Over the last decade, developments in molecular profiling have radically altered the
diagnosis, classification, and management of numerous cancer types, with primary brain …
diagnosis, classification, and management of numerous cancer types, with primary brain …
Histone variants at a glance
Eukaryotic nucleosomes organize chromatin by wrap** 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …
Histone chaperone networks sha** chromatin function
The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …
oligomerization, post-translational modification, nuclear import, stability, assembly and …
Mammalian SWI/SNF continuously restores local accessibility to chromatin
Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF)
binding and requires nucleosomal reorganization. However, it remains unclear how …
binding and requires nucleosomal reorganization. However, it remains unclear how …