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Single-cell sequencing reveals novel proliferative cell type: a key player in renal cell carcinoma prognosis and therapeutic response
B Ye, H Ji, M Zhu, A Wang, J Tang, Y Liang… - Clinical and …, 2024 - Springer
Renal cell carcinoma (RCC) is characterized by a variety of subtypes, each defined by
unique genetic and morphological features. This study utilizes single-cell RNA sequencing …
unique genetic and morphological features. This study utilizes single-cell RNA sequencing …
Bulk and single-nucleus transcriptomics highlight intra-telencephalic and somatostatin neurons in Alzheimer's disease
Cortical neuron loss is a pathological hallmark of late-onset Alzheimer's disease (AD).
However, it remains unclear which neuronal subtypes beyond broad excitatory and …
However, it remains unclear which neuronal subtypes beyond broad excitatory and …
Heterogeneous pseudobulk simulation enables realistic benchmarking of cell-type deconvolution methods
Background Computational cell type deconvolution enables the estimation of cell type
abundance from bulk tissues and is important for understanding tissue microenviroment …
abundance from bulk tissues and is important for understanding tissue microenviroment …
BuDDI: Bulk Deconvolution with Domain Invariance to predict cell-type-specific perturbations from bulk
While single-cell experiments provide deep cellular resolution within a single sample, some
single-cell experiments are inherently more challenging than bulk experiments due to …
single-cell experiments are inherently more challenging than bulk experiments due to …
Performance of computational algorithms to deconvolve heterogeneous bulk ovarian tumor tissue depends on experimental factors
Background Single-cell gene expression profiling provides unique opportunities to
understand tumor heterogeneity and the tumor microenvironment. Because of cost and …
understand tumor heterogeneity and the tumor microenvironment. Because of cost and …
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
Y Ye, A Huang, X Huang, Q **, H Gu, LL Liu, B Yu… - Inflammation …, 2025 - Springer
Background Chronic inflammation is well recognized as a key factor related to renal function
deterioration in patients with diabetic kidney disease (DKD). Neutrophil extracellular traps …
deterioration in patients with diabetic kidney disease (DKD). Neutrophil extracellular traps …
Differences in gene expression profiles in early and late stage rhodesiense HAT individuals in Malawi
T. b. rhodesiense is the causative agent of Rhodesian human African trypanosomiasis (r-
HAT) in Malawi. Clinical presentation of r-HAT in Malawi varies between foci and differs from …
HAT) in Malawi. Clinical presentation of r-HAT in Malawi varies between foci and differs from …
Single Cell Transcriptomics
Kidney is a highly complex organ comprised of diverse cell types and subpopulations. This
cellular complexity complicates efforts to understand both physiology and disease …
cellular complexity complicates efforts to understand both physiology and disease …
Extending the capabilities of deconvolution to provide cell type specific pathway analysis of bulk RNA-seq data for idiopathic pulmonary fibrosis
Motivation Transcriptome data are confounded by differences in cell type proportions.
Differentiating between regulated changes in gene expression and changes due to differing …
Differentiating between regulated changes in gene expression and changes due to differing …
Methods for ChIP-seq Normalization and Their Application for the Analysis of Regulatory Elements in Brain Cells
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has become one of the
major tools to elucidate gene-expression regulation. Similar to other molecular profiling …
major tools to elucidate gene-expression regulation. Similar to other molecular profiling …