Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms

AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …

The vast structural diversity of antimicrobial peptides

J Koehbach, DJ Craik - Trends in pharmacological sciences, 2019 - cell.com
Antimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense.
They have diverse structures and target a variety of organisms, both by nonspecific …

Exploring pathological link between antimicrobial and amyloid peptides

Y Tang, Y Zhang, D Zhang, Y Liu, R Nussinov… - Chemical Society …, 2024 - pubs.rsc.org
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …

[HTML][HTML] An overview of the potentialities of antimicrobial peptides derived from natural sources

I Dini, MG De Biasi, A Mancusi - Antibiotics, 2022 - mdpi.com
Antimicrobial peptides (AMPs) are constituents of the innate immune system in every kind of
living organism. They can act by disrupting the microbial membrane or without affecting …

[HTML][HTML] Antimicrobial Peptides with Anti-Candida Activity

A Perez-Rodriguez, E Eraso, G Quindós… - International journal of …, 2022 - mdpi.com
Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is
the most usual, presenting a high morbidity and mortality. Candida albicans remains the …

Anticancer activities of natural antimicrobial peptides from animals

B Qu, J Yuan, X Liu, S Zhang, X Ma, L Lu - Frontiers in Microbiology, 2024 - frontiersin.org
Cancer is the most common cause of human death worldwide, posing a serious threat to
human health and having a negative impact on the economy. In the past few decades …

Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery

M Song, S Chen, W Lin, K Zhu - Progress in Lipid Research, 2024 - Elsevier
Bacterial infections in humans and animals caused by multidrug-resistant (MDR) pathogens
pose a serious threat to public health. New antibacterial targets are extremely urgent to …

Advances on chemically modified antimicrobial peptides for generating peptide antibiotics

SB Rezende, KGN Oshiro, NGO Júnior… - Chemical …, 2021 - pubs.rsc.org
Antimicrobial peptides (AMPs) are pinpointed as promising molecules against antibiotic-
resistant bacterial infections. Nevertheless, there is a discrepancy between the AMP …

[HTML][HTML] Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistance

AH Benfield, F Vernen, RSE Young, F Nadal-Bufí… - Pharmacological …, 2024 - Elsevier
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and
this is particularly true for patients with metastatic melanoma that carry a BRAF V600E …