Computational Methods for Modeling Lipid-Mediated Active Pharmaceutical Ingredient Delivery
Lipid-mediated delivery of active pharmaceutical ingredients (API) opened new possibilities
in advanced therapies. By encapsulating an API into a lipid nanocarrier (LNC), one can …
in advanced therapies. By encapsulating an API into a lipid nanocarrier (LNC), one can …
Intelligent Design of Lipid Nanoparticles for Enhanced Gene Therapeutics
Lipid nanoparticles (LNPs) are an effective delivery system for gene therapeutics. By
optimizing their formulation, the physiochemical properties of LNPs can be tailored to …
optimizing their formulation, the physiochemical properties of LNPs can be tailored to …
Lipid nanoparticle (LNP) mediated mRNA delivery in cardiovascular diseases: Advances in genome editing and CAR T cell therapy
Cardiovascular diseases (CVDs) are the leading cause of global mortality among non-
communicable diseases. Current cardiac regeneration treatments have limitations and may …
communicable diseases. Current cardiac regeneration treatments have limitations and may …
AI-driven design and optimization of nanoparticle-based drug delivery systems
DU Kapoor, JB Sharma, SM Gandhi… - … and Health Studies, 2024 - li01.tci-thaijo.org
Nanoparticle-based drug delivery systems represent a transformative advancement in
targeted therapeutics, providing meticulous drug delivery, enhanced bioavailability, and …
targeted therapeutics, providing meticulous drug delivery, enhanced bioavailability, and …
Representations of lipid nanoparticles using large language models for transfection efficiency prediction
Abstract Motivation Lipid nanoparticles (LNPs) are the most widely used vehicles for mRNA
vaccine delivery. The structure of the lipids composing the LNPs can have a major impact on …
vaccine delivery. The structure of the lipids composing the LNPs can have a major impact on …
TransMA: an explainable multi-modal deep learning model for predicting properties of ionizable lipid nanoparticles in mRNA delivery
K Wu, Z Wang, X Yang, Y Chen, Z Han… - arxiv preprint arxiv …, 2024 - arxiv.org
As the primary mRNA delivery vehicles, ionizable lipid nanoparticles (LNPs) exhibit
excellent safety, high transfection efficiency, and strong immune response induction …
excellent safety, high transfection efficiency, and strong immune response induction …