Computational Methods for Modeling Lipid-Mediated Active Pharmaceutical Ingredient Delivery

M Paloncýová, M Valério, RN Dos Santos… - Molecular …, 2025 - ACS Publications
Lipid-mediated delivery of active pharmaceutical ingredients (API) opened new possibilities
in advanced therapies. By encapsulating an API into a lipid nanocarrier (LNC), one can …

Intelligent Design of Lipid Nanoparticles for Enhanced Gene Therapeutics

Y Yuan, Y Li, G Li, L Lei, X Huang, M Li… - Molecular …, 2025 - ACS Publications
Lipid nanoparticles (LNPs) are an effective delivery system for gene therapeutics. By
optimizing their formulation, the physiochemical properties of LNPs can be tailored to …

Lipid nanoparticle (LNP) mediated mRNA delivery in cardiovascular diseases: Advances in genome editing and CAR T cell therapy

S Soroudi, MR Jaafari, L Arabi - Journal of Controlled Release, 2024 - Elsevier
Cardiovascular diseases (CVDs) are the leading cause of global mortality among non-
communicable diseases. Current cardiac regeneration treatments have limitations and may …

AI-driven design and optimization of nanoparticle-based drug delivery systems

DU Kapoor, JB Sharma, SM Gandhi… - … and Health Studies, 2024 - li01.tci-thaijo.org
Nanoparticle-based drug delivery systems represent a transformative advancement in
targeted therapeutics, providing meticulous drug delivery, enhanced bioavailability, and …

Representations of lipid nanoparticles using large language models for transfection efficiency prediction

S Moayedpour, J Broadbent, S Riahi, M Bailey… - …, 2024 - academic.oup.com
Abstract Motivation Lipid nanoparticles (LNPs) are the most widely used vehicles for mRNA
vaccine delivery. The structure of the lipids composing the LNPs can have a major impact on …

TransMA: an explainable multi-modal deep learning model for predicting properties of ionizable lipid nanoparticles in mRNA delivery

K Wu, Z Wang, X Yang, Y Chen, Z Han… - arxiv preprint arxiv …, 2024 - arxiv.org
As the primary mRNA delivery vehicles, ionizable lipid nanoparticles (LNPs) exhibit
excellent safety, high transfection efficiency, and strong immune response induction …