Immunopathology of RSV: an updated review

HC Bergeron, RA Tripp - Viruses, 2021‏ - mdpi.com
RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

Bronchiolitis needs a revisit: distinguishing between virus entities and their treatments

T Jartti, HH Smits, K Bønnelykke, O Bircan, V Elenius… - Allergy, 2019‏ - Wiley Online Library
Current data indicate that the “bronchiolitis” diagnosis comprises more than one condition.
Clinically, pathophysiologically, and even genetically three main clusters of patients can be …

Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis

KH Antunes, RT Stein, C Franceschina, EF da Silva… - …, 2022‏ - thelancet.com
Background Gut microbiota-derived short-chain fatty-acid (SFCA) acetate protects mice
against RSV A2 strain infection by increasing interferon-β production and expression of …

Nebulised ALX-0171 for respiratory syncytial virus lower respiratory tract infection in hospitalised children: a double-blind, randomised, placebo-controlled, phase 2b …

S Cunningham, PA Piedra… - The Lancet …, 2021‏ - thelancet.com
Background Respiratory syncytial virus (RSV) is the most common cause of severe lower
respiratory tract infection, with a high global health burden. There are no effective treatments …

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

MS Habibi, RS Thwaites, M Chang, A Jozwik, A Paras… - Science, 2020‏ - science.org
INTRODUCTION Even with intimate exposure to a virus, some people fail to become
infected. Variable transmission partly depends on the dose and duration of exposure but is …

[HTML][HTML] Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies

Z Shang, S Tan, D Ma - International Journal of Biological Sciences, 2021‏ - ncbi.nlm.nih.gov
Respiratory syncytial virus (RSV) is one of the most important viral pathogens causing
respiratory tract infection in infants, the elderly and people with poor immune function, which …

Early-life respiratory syncytial virus disease and long-term respiratory health

HJ Zar, F Cacho, T Kootbodien, A Mejias… - The Lancet …, 2024‏ - thelancet.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection
(LRTI), hospital admission, and mortality in children worldwide. Early-life RSV LRTI has also …

Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome

T Flerlage, JC Crawford, EK Allen, D Severns… - Nature …, 2023‏ - nature.com
Acute respiratory distress syndrome (ARDS), termed pediatric ARDS (pARDS) in children, is
a severe form of acute respiratory failure (ARF). Pathologic immune responses are …

Respiratory syncytial virus (RSV): a scourge from infancy to old age

JA Coultas, R Smyth, PJ Openshaw - Thorax, 2019‏ - thorax.bmj.com
Respiratory syncytial virus (RSV) is the most common single cause of respiratory
hospitalisation of infants and is the second largest cause of lower respiratory infection …

[HTML][HTML] Does respiratory syncytial virus lower respiratory illness in early life cause recurrent wheeze of early childhood and asthma? Critical review of the evidence …

AJ Driscoll, SH Arshad, L Bont, SM Brunwasser… - Vaccine, 2020‏ - Elsevier
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection (LRTI)
and hospitalization in infants and children globally. Many observational studies have found …