Roles of the sister chromatid cohesion apparatus in gene expression, development, and human syndromes
D Dorsett - Chromosoma, 2007 - Springer
The sister chromatid cohesion apparatus mediates physical pairing of duplicated
chromosomes. This pairing is essential for appropriate distribution of chromosomes into the …
chromosomes. This pairing is essential for appropriate distribution of chromosomes into the …
Cohesinopathies, gene expression, and chromatin organization
The cohesin protein complex is best known for its role in sister chromatid cohesion, which is
crucial for accurate chromosome segregation. Mutations in cohesin proteins or their …
crucial for accurate chromosome segregation. Mutations in cohesin proteins or their …
Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons
Cohesin is a highly conserved multisubunit complex that holds sister chromatids together in
mitotic cells. At the metaphase to anaphase transition, proteolytic cleavage of the α kleisin …
mitotic cells. At the metaphase to anaphase transition, proteolytic cleavage of the α kleisin …
piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning
O Schuldiner, D Berdnik, JM Levy, JS Wu… - Developmental cell, 2008 - cell.com
Developmental axon pruning is widely used to refine neural circuits. We performed a mosaic
screen to identify mutations affecting axon pruning of Drosophila mushroom body γ neurons …
screen to identify mutations affecting axon pruning of Drosophila mushroom body γ neurons …
Cohesin forms fountains at active enhancers in C. elegans
Transcriptional enhancers must find their target genes both efficiently and specifically.
Chromatin conformation capture revealed the critical function of three-dimensional …
Chromatin conformation capture revealed the critical function of three-dimensional …
How cohesin and CTCF cooperate in regulating gene expression
Cohesin is a DNA-binding protein complex that is essential for sister chromatid cohesion
and facilitates the repair of damaged DNA. In addition, cohesin has important roles in …
and facilitates the repair of damaged DNA. In addition, cohesin has important roles in …
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance
Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin
onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a …
onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a …
The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length
C Bénard, B McCright, Y Zhang, S Felkai, B Lakowski… - 2001 - journals.biologists.com
The Caenorhabditis elegans maternal-effect clk genes are involved in the temporal control
of development and behavior. We report the genetic and molecular characterization of clk-2 …
of development and behavior. We report the genetic and molecular characterization of clk-2 …
Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans
The regulation of cell migration is essential to animal development and physiology. Heparan
sulfate proteoglycans shape the interactions of morphogens and guidance cues with their …
sulfate proteoglycans shape the interactions of morphogens and guidance cues with their …
Regulators of the cohesin network
B **ong, JL Gerton - Annual review of biochemistry, 2010 - annualreviews.org
Chromosome cohesion is the term used to describe the cellular process in which sister
chromatids are held together from the time of their replication until the time of separation at …
chromatids are held together from the time of their replication until the time of separation at …